During her tenure as a police officer Misty became good friends with Colleen Wing after saving her life during a shootout. Unable to continue active duty after being injured, losing her arm, Misty rejected settling for a desk job and instead left the NYPD to start a private investigation business with Colleen; Nightwing Restorations, LTD. The two specialized in missing persons cases, and came to be known as the Daughters of the Dragon for their training in Eastern martial arts and Colleen's samurai sword skills.
The Daughters of the Dragon have frequently teamed up with Iron Fist and Luke Cage, along with the Heroes for Hire. Misty has long been romantically linked with Danny Rand, the immortal Iron Fist. Kinght also briefly romanced Tyrone King when Rand was believed dead. Knight believed Danny Rand to be alive and went to great lengths to investigate. With the aid of Colleen Wing and the Sub-Mariner, Misty was eventually able to find Iron Fist, rescue him from his captors, and return him to society.
Misty Knight and Coleen Wing were contacted by Iron Man, Reed Richards, and Spider-Man to reform Heroes for Hire in order to track down superhumans refusing to comply with the Superhuman Registration Act. Initially hesitant, the pair eventually created a team including Shang-Chi, Humbug, Orka, Black Cat, Paladin and a new Tarantula.